Nucleic acid and amino acid sequences of infectious salmon...

A - Human Necessities – 61 – K

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Details

A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 48/00 (2006.01) C07K 14/11 (2006.01) C12N 15/40 (2006.01) C12N 15/44 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2378437

The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce an immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.

La présente invention concerne l'utilisation de séquences d'acide nucléique et/ou de séquences d'acides aminés dans la préparation d'un vaccin visant à la protection de poissons contre le virus de l'anémie infectieuse du saumon. Spécifiquement, ces vaccins contiennent au moins une séquence d'acide nucléique laquelle est dérivée du ISAV ou des analogues préparés par synthèse de celui-ci, ou bien des séquences sensiblement homologues. Ces séquences d'acide nucléique sont transcrites et traduites en séquences peptidiques lesquelles sont incorporées dans une stratégie de vaccination pour induire une réponse immune aux antigènes de surface du ISAV et par conséquent au ISAV lui-même. Par conséquent, à la fois l'utilisation du vaccin contre le ISAV et l'incorporation de séquences peptidiques sont ici décrites.

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