Nucleic acid and corresponding protein entitled 121p1f1...

Details Nucleic acid and corresponding protein entitled 121p1f1... Nucleic acid and corresponding protein entitled 121p1f1...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2440147

A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P1F1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P1F1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P1F1 can be used in active or passive immunization.

La présente invention concerne un gène (appelé 121P1F1) et la protéine qu'il code, ainsi que des variants de ceux-ci. 121P1F1 présente une expression spécifique au tissu dans un tissu adulte normal et est exprimé de manière aberrante en cas de cancers listés dans le tableau I. 121P1F1 fournit ainsi une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène 121P1F1 ou un fragment de celui-ci ou la protéine qu'il code ou des variants de ceux-ci ou un fragment de ceux-ci peuvent être utilisés pour provoquer une réponse immunitaire humorale ou cellulaire. Des anticorps ou des lymphocytes T réagissant avec 121P1F1 peuvent être utilisés dans le cadre d'une immunisation active ou passive.

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