Nucleic acid and corresponding protein entitled 125p5c8...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2440658

A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.

L'invention concerne un nouveau gène (désigné sous le nom de 125P5C8), sa protéine codée, et des variants de celui-ci. Ce gène 125P5C8 présente une expression spécifique aux tissus dans des tissus adultes normaux, il s'exprime sous une forme aberrante dans de multiples cancers répertoriés dans la table I. Par conséquent, le gène 125P5C8 fournit une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour ces cancers. Le gène 125P5C8, ou son fragment, ou sa protéine codée, ou ses variants, ou un fragment de celui-ci, peut être utilisé afin de mettre en lumière une réponse immune humorale ou cellulaire; des anticorps ou des lymphocytes T réactifs avec 125P5C8 peuvent être utilisés dans une immunisation active ou passive.

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