Nucleic acid and corresponding protein entitled 158p3d2...

Details Nucleic acid and corresponding protein entitled 158p3d2... Nucleic acid and corresponding protein entitled 158p3d2...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 51/00 (2006.01) A61M 36/14 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/3

Patent

CA 2442993

A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.

L'invention concerne un nouveau gène (appelé 150P3D2) et sa protéine codée ainsi que des variants de celle-ci, le gène 158P3D2 présentant une expression à spécificité tissulaire dans du tissu adulte normal, et est exprimé de façon aberrante dans les cancers listés dans la table I. Par conséquent, le 158P3D2 fournit une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène 158P3D2 ou son fragment, ou sa protéine codée ou des variants de celle-ci, ou un fragment de ceux-ci, peuvent être utilisés pour mettre en lumière une réponse immune humorale ou cellulaire; des anticorps ou des cellules T réagissant avec 158P3D2 peuvent être utilisés dans l'immunisation active ou passive.

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