Nucleic acid and corresponding protein named 158p1d7 useful...

Details Nucleic acid and corresponding protein named 158p1d7 useful... Nucleic acid and corresponding protein named 158p1d7 useful...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2515699

A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

L'invention porte sur un nouveau gène (dit 158P1D7) et la protéine pour laquelle il code, qui alors qu'il produit une expression spécifique d'un tissu pour les tissus adultes normaux, produit une expression aberrante dans différents tissus cancéreux (cf tableau 1). Par conséquent, le 158P1D7 s'avère une cible utile pour le diagnostique et/ou la thérapie du cancer. En outre le gène 158P1D7 ou ses fragments peuvent servir à provoquer une réponse immunitaire.

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