Nucleic acid and polypeptide sequences from lawsonia...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/31 (2006.01) A61K 39/02 (2006.01) C07H 21/00 (2006.01) C07K 14/195 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2501238

The present invention provides nucleic acid molecules unique to L. intracellularis. The invention also provides the polypeptides encoded by the L. intracellularis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the L. intracellularis-specific nucleic acid molecules. The invention further provides for methods of detecting L. intracellularis in a sample using nucleic acid molecules, polypeptides, and antibodies of the invention. The invention additionally provides methods of preventing a L. intracellularis infection in an animal.

La présente invention concerne des molécules d'acide nucléique spécifiques à <I>L</I>.intracellularis. L'invention concerne également les polypeptides codés par les molécules d'acide nucléique spécifiques à L. intracellularis de l'invention, et des anticorps présentant une affinité de liaison spécifique aux polypeptides codés par les molécules d'acide nucléique spécifiques à L. intracellularis. L'invention concerne également des méthodes de détection de L. intracellularis dans un échantillon à l'aide des molécules d'acide nucléique, des polypeptides, et des anticorps de l'invention. L'invention concerne, de plus, des méthodes de prévention d'une infection par L. intracellularis d'un animal.

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