Nucleic acid-based tests for prenatal gender determination

Details Nucleic acid-based tests for prenatal gender determination Nucleic acid-based tests for prenatal gender determination

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2717320

Provided herein are compositions, processes and kits for noninvasive, early determination of fetal sex from, and/or amount of fetal nucleic acid in, an extracellular nucleic acid sample from a pregnant female. Such compositions, processes and kits are useful for detection of low genomic copy numbers of male fetal nucleic acid in a high copy number background of female nucleic acid, thereby determining the sex of a fetus and/or amount of fetal nucleic acid in a sample.

La présente invention concerne des compositions, des procédés, et des nécessaires, pour déterminer de manière précoce et non invasive, le sexe d'un ftus, et/ou une quantité dADN ftal, à partir dun échantillon dADN extra-cellulaire prélevé chez une femme enceinte. Ces compositions, procédés, et nécessaires, sont utiles pour détecter des séquences dADN ftal masculin à faible nombre de copies génomiques dans un contexte de séquences dADN féminin à fort nombre de copies, ce qui permet ainsi de déterminer le sexe d'un ftus et/ou une quantité dADN ftal dans un échantillon.

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