Nucleic acid capable of binding to immunoglobulin g and use...

Details Nucleic acid capable of binding to immunoglobulin g and use... Nucleic acid capable of binding to immunoglobulin g and use...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 1/22 (2006.01) G01N 33/543 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2614145

A novel aptamer against IgG, use of the aptamer and others. More specifically, an aptamer capable of binding to the Fc segment of IgG (e.g., human IgG); a complex comprising the aptamer and a functional substance bound to the aptamer (e.g., an affinity substance, a labeling substance, an enzyme, a medicinal substance, a toxin, a drug delivery medium); a solid support having the aptamer or the complex immobilized thereto; a device for medical purposes comprising the solid support; a method for purification of an antibody, comprising holding an IgG antibody by adsorption on the solid support and eluting the adsorbed IgG antibody with an eluent; a process for producing a purified antibody, comprising preparing an IgG antibody and purifying the IgG antibody using the solid support; and others.

L'invention concerne, entre autres, un nouvel aptamère contre les IgG, son utilisation. Plus spécifiquement, elle concerne un nouvel aptamère capable de se lier au segment Fc d'une IgG (par exemple une IgG humaine) ; un complexe comprenant, entre autres, l'aptamère et une substance fonctionnelle liée à l'aptamère (par exemple une substance d'affinité, de marquage, une enzyme, une substance médicinale, une toxine, un milieu d'administration médicamenteuse) ; un support solide ayant l'aptamère ou le complexe immobilisé sur celui-ci ; un dispositif à des fins médicales comprenant ce support solide ; un procédé de purification d'un anticorps, comprenant le maintien d'un anticorps IgG par adsorption sur le support solide et l'élution de l'anticorps adsorbé avec un éluant ; un processus de production d'un anticorps purifié, comprenant la préparation d'un anticorps IgG et sa purification en utilisant le support solide .

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