Nucleic acid coated particles

Details Nucleic acid coated particles Nucleic acid coated particles

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 9/00 (2006.01) A61K 38/02 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2500215

Particles are provided which are suitable for delivery from a particle- mediated delivery device. The particles are obtained by precipitating a nucleic acid on inert metal carrier particles in the presence of a nucleic acid condensing agent and a metal ion chelating agent. Also described are processes for preparing the particles, and therapeutic methods using the particles including methods of nucleic acid immunisation and gene therapy.

L'invention concerne des particules convenant à une administration à partir d'un dispositif d'administration dont ces particules assurent la médiation. Les particules sont obtenues par précipitation d'un acide nucléique sur des particules de support métallique inerte en présence d'un agent de condensation d'acide nucléique et d'un agent chélatant d'ion métallique. Elle concerne aussi des procédés de préparation des particules, et des méthodes thérapeutiques utilisant ces particules y comprises des méthodes d'immunisation par acide nucléique et de thérapie génique.

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