Nucleic acid coding for human angiotensin converting enzyme...

C - Chemistry – Metallurgy – 12 – N

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150/15, 195/1.11

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12P 21/02 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1340868

L'invention concerne le clonage et le séquençage de l'acide nucleique codant pour l'ECA humaine ainsi que la determination de la chaîne peptidique correspondant à l'ECA et de fragments peptidiques actifs qui en decoulent. L'invention a également pour objet l'utilisation des polypeptides sus-mentionnés pour la mise en oeuvre de méthodes de diagnostic in vitro de l'hypertension, pour l'étude conceptuelle de nouveaux inhibiteurs de l'ECA. L'invention concerne également l'utilisation des sondes nucléotidiques de l'invention pour le depistage in vitro des polymorphismes du gène codant pour l'ECA.

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