Nucleic acid compounds for inhibiting birc5 gene expression...

Details Nucleic acid compounds for inhibiting birc5 gene expression... Nucleic acid compounds for inhibiting birc5 gene expression...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2733142

The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing BIRC5 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double--stranded regions separated by a nick or gap wherein one strand is complementary to a BIRC5 mRNA. Also provided are methods of decreasing expression of a BIRC5 gene in a cell or in a subject to treat a BIRC5-related disease.

La présente invention concerne des molécules dARN, par exemple, des molécules dacide ribonucléique meroduplex (ARNmd), capables d'entraîner une réduction ou un silençage de lexpression du gène BIRC5. Un ARNmd de la présente invention comprend au moins trois brins qui se combinent pour former au moins deux régions bicaténaires non chevauchantes séparées par une coupure ou une brèche où un brin est complémentaire dun ARNm BIRC5. La présente invention concerne en outre des procédés de réduction de lexpression dun gène BIRC5 dans une cellule ou chez un sujet pour traiter une maladie liée à BIRC5.

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