Nucleic acid compounds for inhibiting gene expression and...

Details Nucleic acid compounds for inhibiting gene expression and... Nucleic acid compounds for inhibiting gene expression and...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2677068

The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), and blunt ended double-stranded ribonucleic acid molecules capable of decreasing or silencing expression of a target gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a target mRNA. Also provided are methods of decreasing expression of a target gene in a cell or in a subject to treat a disease or condition associated with the target gene.

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