Nucleic acid compounds for inhibiting plk1 gene expression...

Details Nucleic acid compounds for inhibiting plk1 gene expression... Nucleic acid compounds for inhibiting plk1 gene expression...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2733204

The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing gene expression of PLKl gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a PLKl mRNA. Also provided are methods of decreasing expression of a PLKl gene in a cell or in a subject to treat a PLK family member-related disease.

La présente invention concerne des molécules dARN, par exemple, des molécules dacide ribonucléique meroduplex (ARNmd), capables d'entraîner une réduction ou un silençage de lexpression génique du gène PLK1. Un ARNmd de la présente invention comprend au moins trois brins qui se combinent pour former au moins deux régions bicaténaires non chevauchantes séparées par une coupure ou une brèche où un brin est complémentaire dun ARNm PLK1. La présente invention concerne en outre des procédés de réduction de lexpression dun gène PLK1 dans une cellule ou chez un sujet pour traiter une maladie liée à un membre de la famille PLK.

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