C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 35/76 (2006.01) A61P 37/04 (2006.01) C07K 16/08 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 7/01 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2558685
It is intended to provide a method of efficiently replicating RNA containing the full-length genome sequence of HCV; a method of preparing viral particles of HCV containing full-length HCV replicon RNA or full-length HCV genome RNA by using a cell culture system; a method of producing hepatitis C viral particles which comprises culturing cells having replicon RNA comprising the full-length RNA sequence of hepatitis C virus of the genotype 2a and a base sequence containing at least one selection marker and/or at least one reporter gene and at least one IRES sequence or the full-length genome RNA of hepatitis C virus of the genotype 2a to thereby allowing the production of viral particles in the culture medium; a hepatitis C vaccine; and an antibody against hepatitis C viral particles.
L'intention est de fournir un procédé de réplication efficace de l'ARN contenant la séquence du génome complet du VHC ; un procédé de préparation de particules virales de VHC contenant l'ARN réplicon du VHC complet ou l'ARN du génome complet du VHC en utilisant un système de culture de cellules ; un procédé de production de particules virales d'hépatite C qui comprend de mettre en culture des cellules ayant l'ARN réplicon comprenant la séquence complète de l'ARN du virus de l'hépatite C du génotype 2a et une séquence de base contenant au moins un marqueur de sélection et/ou au moins un gène reporteur et au moins une séquence IRES ou l'ARN du génome complet du virus de l'hépatite C du génotype 2a pour permettre de cette manière la production de particules virales dans le milieu de culture ; vaccin contre l'hépatite C ; et anticorps contre les particules virales d'hépatite C.
Date Tomoko
Kato Takanobu
Miyamoto Michiko
Sone Saburo
Tanabe Jun-Ichi
Smart & Biggar
Tokyo Metropolitan Institute Of Medical Science
Tokyo Metropolitan Organization For Medical Research
Toray Industries Inc.
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