Nucleic acid construct for optimized production of products

Details Nucleic acid construct for optimized production of products Nucleic acid construct for optimized production of products

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/605 (2006.01) C07K 14/655 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2391906

The present invention features a nucleic acid construct for expressing a product, e.g., a small peptide such as GLP-1. The construct includes a nucleic acid sequence encoding a signal peptide and a nucleic acid sequence which encodes the pro-region of somatostatin or a functional fragment thereof. The construct can further include a sequence encoding the small peptide or the construct can be used to express an endogenous genomic sequence encoding the small peptide. The present invention further features genetically engineered cells, and methods of using such constructs or cells.

L'invention porte sur un produit d'assemblage d'acides nucléiques servant à exprimer un produit, par exemple un petit peptide tel que le GLP-1. Ledit produit d'assemblage comprend une séquence d'acides nucléiques codant pour un peptide signal et une séquence d'acides nucléiques codant pour la pro-région de la somatostatine ou l'un de ses fragments fonctionnels. Ledit produit d'assemblage peut en outre comprendre une séquence codant pour le petit peptide ou servir à exprimer une séquence de génomes endogènes codant pour le petit peptide. L'invention porte également sur des cellules obtenues par génie génétique et sur des procédés d'utilisation desdits produits d'assemblage ou desdites cellules.

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