C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2675967
The present invention is directed to recombinant constructs and methods for treating pathological conditions associated with H19 expression, such as tumors characterized by up-regulated expression of H19 RNA. Specifically, the recombinant constructs of the invention comprise at least one nucleic acid sequence encoding a small interfering RNA (siRNA) molecule directed to H19, the nucleic acid sequence being operably linked to at least one H19-specific transcription-regulating sequence. Vectors comprising these constructs, pharmaceutical compositions comprising them and therapeutic methods of using same are also provided.
L'invention porte sur des produits de recombinaison et des procédés permettant de traiter des états pathologiques associés à l'expression de H19, par exemple des tumeurs caractérisées par une régulation positive de l'expression de l'ARN H19. En particulier, les produits de recombinaison de l'invention comprennent au moins une séquence nucléotidique codant une molécule de petit ARN interférant (ARNsi) dirigée contre H19, la séquence nucléotidique étant fonctionnellement liée à au moins une séquence régulatrice de la transcription spécifique de H19. L'invention concerne également des vecteurs comprenant lesdits produits de recombinaison, des compositions pharmaceutiques les renfermant et des procédés thérapeutiques d'utilisation de ces derniers.
Ridout & Maybee Llp
Yissum Research Development Company Of The Hebrew University Of
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