Nucleic acid constructs containing hybrid promoters for use...

Details Nucleic acid constructs containing hybrid promoters for use... Nucleic acid constructs containing hybrid promoters for use...

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2211008

Nucleic acid constructs containing hybrid promoters for use in gene therapy and genetic manipulation. The invention relates to a nucleic acid construct for the precise, regulated expression of genes in host cells, which construct exhibits at least one mutation which inhibits the proper expression of the expressed gene and exhibits at least one additional second mutation which relieves the inhibition due to the first mutation, to an isolated cell which harbors the nucleic acid construct, and to the use of the nucleic acid construct for preparing pharmaceuticals and for treating diseases with excessive cell proliferation.

Construits d'acide nucléique contenant des promoteurs hybrides pour utilisation en génothérapie et dans les manipulations génétiques. L'invention concerne un construit d'acide nucléique pour l'expression précise et régulée de gènes dans des cellules hôtes, lequel construit porte au moins une mutation qui inhibe l'expression appropriée du gène exprimé et présente au moins une seconde mutation qui lève l'inhibition causée par la première mutation, une cellule isolée qui porte le construit d'acide nucléique et l'utilisation du construit d'acide nucléique pour préparer des produits pharmaceutiques et pour traiter des maladies caractérisées par une prolifération cellulaire excessive.

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