Nucleic acid constructs for gene therapy whose activity is...

Details Nucleic acid constructs for gene therapy whose activity is... Nucleic acid constructs for gene therapy whose activity is...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2255141

The present application discloses nucleic acid constructs for the gene therapy of diseases, which constructs comprise nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, mutants thereof, some of which possess a dominant interfering character, and the use of these nucleic acids for the prophylaxis and therapy of diseases.

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