Nucleic acid constructs for genetic immunization

Details Nucleic acid constructs for genetic immunization Nucleic acid constructs for genetic immunization

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) C07K 14/02 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C12N 9/72 (2006.01) C12N 15/49 (2006.01) C12N 15/51 (2006.01) C12N 15/55 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01)

Patent

CA 2349505

Recombinant nucleic acid molecules are described. The molecules have a first sequence encoding a Hepatitis B virus core antigen and a second sequence encoding at least one T cell epitope inserted within the first sequence. Vectors and compositions containing these molecules are also described. Methods of eliciting an immune response using these molecules are also described.

L'invention concerne des molécules de recombinaison d'acide nucléique. Ces molécules possèdent une première séquence codant pour un antigène capsidique du virus de l'hépatite B et une seconde séquence codant pour au moins un épitope de lymphocyte T inséré dans la première séquence. L'invention concerne également des vecteurs et des compositions contenant ces molécules. L'invention concerne également des méthodes permettant d'éliciter une réponse immunitaire au moyen de ces molécules.

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