C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2211162
Pharmaceutical composition useful for transfecting a nucleic acid and characterised in that it contains, in addition to said nucleic acid, at least one transfecting agent and a compound causing the condensation of said nucleic acid, wherein said compound is totally or partly derived from a histone, a nucleoline, a protamine and/or a derivative thereof. The use of said composition for transferring nucleic acids in vitro, ex vivo and/or in vivo is also described.
La présente invention concerne une composition pharmaceutique utile pour la transfection d'un acide nucléique caractérisée en ce qu'elle contient outre ledit acide nucléique, au moins un agent de transfection et un composé intervenant au niveau de la condensation dudit acide nucléique, ledit composé dérivant en tout ou partie d'une histone, d'une nucléoline, d'une protamine et/ou de l'un de leurs dérivés. Elle se rapporte en outre à l'utilisation de ladite composition pour le transfert in vitro, ex vivo et/ou in vivo d'acides nucléiques.
Byk Gerardo
Scherman Daniel
Schwartz Bertrand
Aventis Pharma S.a.
Rhone-Poulenc Rorer S.a.
Robic
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