Nucleic acid damage using riboflavin and light

A - Human Necessities – 61 – K

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Details

A61K 41/00 (2006.01) A61K 35/14 (2006.01) A61L 2/00 (2006.01) A61L 2/08 (2006.01) A61L 2/10 (2006.01) C12N 7/04 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2495909

A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

L'invention concerne un procédé destiné à endommager et à entretenir les dégâts causés à des acides nucléiques de pathogènes tels que des globules blancs, des bactéries et des virus pouvant être contenus dans le sang ou dans des composants du sang. Ce procédé consiste à ajouter dans le sang ou dans un composant du sang contenant des pathogènes une quantité efficace de riboflavine, et à exposer le fluide à une lumière ayant une longueur d'onde appropriée en vue d'endommager les acides nucléiques du pathogène et sensiblement entretenir les dégâts causés à ces acides nucléiques pathogéniques afin de permettre leur transfusion ultérieure dans un récipient.

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