A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2393526
The present invention is directed to a composition and pharmaceutical preparations for introducing nucleic acids including oligo- or poly-nucleotide into cells in a host tissue by a delivery system and a method of preparing such a composition. The composition for delivery of nucleic acids comprises polymeric carrier particles that are essentially free of groups having a positive electric charge and the nucleic acids are provided essentially on the surface of the particles. The carrier particle is insoluble in water but suitably it is able to absorb water quickly.
La présente invention concerne une composition et des préparations pharmaceutiques permettant d'introduire des acides nucléiques comprenant un oligonucléotide ou un polynucléotide dans les cellules d'un tissu hôte, au moyen d'un système d'administration et d'une méthode de préparation d'une telle composition. Cette composition destinée à l'administration d'acides nucléiques comprend des particules support polymères essentiellement exemptes de groupes possédant une charge électrique positive, les acides nucléiques se trouvant essentiellement sur la surface de ces particules. Cette particule support est insoluble dans l'eau mais peut en absorber rapidement de manière avantageuse.
Artursson Per
Blum Holly
Artursson Per
Blum Holly
Fetherstonhaugh & Co.
Merck Patent Gmbh
Pharmaconcepts Ab
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