Nucleic acid delivery vehicle

Details Nucleic acid delivery vehicle Nucleic acid delivery vehicle

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 38/37 (2006.01) A61K 38/48 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2231172

A composition is provided comprising a liposome which has a polynucleic acid and a peptide capable of disrupting membranes under acidic conditions encapsulated within it. The composition is used for efficient transfer of nucleic acids into cells both in vitro as well as in vivo.

L'invention porte sur une composition comportant un liposome encapsulant un acide polynucléique et un peptide susceptible de rompre des membranes dans des conditions acides. Ladite composition permet un transfert efficace d'acide nucléique dans des cellules tant in vitro qu'in vivo.

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