Nucleic acid detection method having increased sensitivity

Details Nucleic acid detection method having increased sensitivity Nucleic acid detection method having increased sensitivity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/28 (2006.01)

Patent

CA 2545356

The present disclosure relates to methods of detecting nucleic acid hybridization by monitoring an output signal. Some advantageous embodiments include techniques which can augment the signal. One such technique involves catalytic detection, such as with a peroxidase or other enzyme. Another technique involves "on-chip" amplification to enlarge the nucleic acid after hybridization has occurred.

Cette invention se rapporte à des procédés pour détecter l'hybridation d'acides nucléiques en surveillant un signal de sortie. Dans des modes de réalisation avantageux, on utilise des techniques qui permettent d'augmenter ce signal. L'une de ces techniques implique une détection catalytique, par exemple au moyen d'une peroxydase ou d'une autre enzyme. D'autres techniques impliquent une amplification sur puce qui prolonge l'acide nucléique, après que l'hybridation se soit produite.

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