C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2251262
A novel nucleic acid sequence encoding for a mammalian voltage-gated, preferablyTTX-resistant, sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these sequences, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, preferably tetrodotoxin-resistant, sodium channel as a therapeutic target for compounds.
Dietrich Paul Shartzer
Fish Linda Marie
Khare Reena
Rabert Douglas Kenneth
Sangameswaran Lakshmi
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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