C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2222371
An isolated nucleic acid melocule is provided which encodes a mammalian signal mediator protein involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing several SH2 binding motifs, and a carboxy-terminal effector domain that can induce pseudohyphal budding in yeast. The invention also provides the novel signal mediator protein, and antibodies thereto. These biological molecules are useful as research tools and as diagnostic and therapeutic agents for the identification, detection and regulation of complex signaling events leading to morphological, potentially neoplastic, cellular changes.
L'invention porte sur une molécule isolée d'acide nucléique codant pour une protéine signal médiatrice de mammifère intervenant dans la régulation des modifications de la morphologie cellulaire. Ladite protéine comporte un domaine N-Terminal SH3, un domaine interne contenant plusieurs motifs de fixation SH2, et un domaine effecteur C-Terminal pouvant induire un bourgeonnement pseudo-mycélien dans la levure. L'invention porte également sur cette nouvelle protéine signal médiatrice et sur les anticorps dirigés contre celle-ci. Ces molécules biologiques sont d'utiles outils de recherche et agents diagnostiques et thérapeutiques pouvant servir à l'identification, à la détection et à la régulation d'événements de signalisation complexes précurseurs de modifications cellulaires morphologiques ou potentiellement néoplasiques.
Estojak Joanne
Golemis Erica A.
Law Susan F.
Borden Ladner Gervais Llp
Fox Chase Cancer Center
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