C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2208052
An isolated nucleic acid is provided which encodes a transiently-expressed kinetochore protein, CENP-F. Also provided are the purified polypeptide encoded by the nucleic acid sequence, and antibodies immunologically specific for the polypeptide. These biological molecules are useful as markers of cellular proliferation, particularly for the identification of cells in the G2 and M phases of the cell cycle. Methods are provided for using the nucleic acid, protein and antibodies for assessing cellular proliferation in biological fluids and tissue samples, and for detecting the presence of autoantibodies to the protein.
On a isolé un acide nucléique qui code une protéine de centromère à expression transitoire, CENP-F. On décrit aussi le polypeptide purifié codé par cette séquence d'acide nucléique, et des anticorps immunologiquement spécifiques de ce polypeptide. Ces molécules biologique servent de marqueurs de la prolifération cellulaire et surtout à identifier des cellules se trouvant dans les phases G2 et M du cycle cellulaire. Des procédés permettent d'utiliser cet acid nucléique, cette protéine et ces anticorps pour évaluer une prolifération cellulaire dand des échantillons de fluides et de tissus biologiques et pour détecter la présence d'auto-anticorps de cette protéine.
Rattner Jerome B.
Yen Timothy J.
Borden Ladner Gervais Llp
Fox Chase Cancer Center
University Technologies International Inc.
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