Nucleic acid encoding hyaluronan synthase and methods of use

Details Nucleic acid encoding hyaluronan synthase and methods of use Nucleic acid encoding hyaluronan synthase and methods of use

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/102 (2006.01) C12N 1/00 (2006.01) C12N 1/15 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12P 19/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2326821

The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active bacterial multocida hyaluronate synthase (PmHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan. The present invention also relates to the use of the PmHAS in constructing "knock-out" mutant strains of P. multocida for use in vaccinations. The present invention further relates to the use of the PmHAS in diagnostic tests in the field determinations of livestock P. multocida infection.

Dans la présente invention, on divulgue un segment d'acide nucléique possédant un segment de codage de région codant une hyaluronate-synthase de bactérie multocida à activité enzymatique (PmHAS), et également l'utilisation de ce segment d'acide nucléique pour la préparation de cellules recombinantes produisant une hyaluronate-synthase et son produit l'acide hyaluronique. Le hyaluronate est également connu sous le nom d'acide hyaluronique ou de hyaluronan. Dans la présente invention, on divulgue aussi l'utilisation de PmHAS pour l'élaboration de souches mutantes "inactivées" de P. multocida à des fins d'utilisation dans des vaccins. Dans la présente invention, on divulgue de plus l'utilisation de PmHAS dans des tests de diagnostic lors des déterminations sur le terrain d'une infection du bétail par P. multocida.

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