C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2593548
The present invention provides a colorimetric light-up sensor for determining the presence and optionally the concentration of an analyte in a sample. Methods of utilizing the sensor and kits that include the sensor also are provided. The sensor utilizes nucleic acid enzymes that ligate substrate fragments to form aggregates from the resulting substrate and oligonucleotide functionalized particles. The nucleic acid enzymes useful in the ligation may include DNA and RNA based enzymes and enzymes modified with aptamer components to form aptazymes.
L'invention concerne un capteur lumineux colorimétrique qui permet de déterminer la présence, et éventuellement la concentration, d'un analyte contenu dans un échantillon. L'invention concerne également des procédés d'utilisation du capteur et des kits contenant le capteur. Le capteur fait intervenir des enzymes d'acide nucléique qui ligaturent les fragments de substrat pour former des agrégats à partir du substrat obtenu et des particules fonctionnalisées par oligonucléotide. Les enzymes d'acide nucléique utilisées dans la ligation peuvent contenir des enzymes d'ADN et d'ARN ainsi que des enzymes modifiées au moyen de composants d'aptamères pour former des aptazymes.
Liu Juewen
Lu Yi
Barrigar Intellectual Property Law
The Board Of Trustees Of The University Of Illinois
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