C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/43 (2006.01) A61K 48/00 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12Q 1/34 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2323069
A nucleic acid enzyme showing an allosteric RNA-cleaving activity on a target RNA; an expression vector containing a DNA encoding this nucleic acid enzyme; a process for producing the above nucleic acid enzyme characterized by effecting transcription onto RNA with the use as a template of the above expression vector containing the DNA encoding the nucleic acid enzyme; medicinal compositions containing as the active ingredient the above nucleic acid enzyme or the expression vector containing the DNA encoding the nucleic acid enzyme; and a method of specifically cleaving the target RNA by using the nucleic acid enzyme.
L'invention concerne une enzyme d'acide nucléique ayant une activité de clivage d'ARN allostérique sur un ARN cible; un vecteur d'expression contenant un ADN codant pour ladite enzyme d'acide nucléique; un procédé de production de ladite enzyme d'acide nucléique, qui se caractérise par une transcription sur l'ARN, à l'aide d'une matrice du vecteur d'expression susmentionné contenant l'ADN codant pour l'enzyme d'acide nucléique; des compositions médicinales contenant, en tant que principe actif, ladite enzyme d'acide nucléique ou le vecteur d'expression contenant l'ADN codant pour l'enzyme d'acide nucléique; et un procédé de clivage spécifique de l'ARN cible au moyen de l'enzyme d'acide nucléique.
Hitoshio Akio
Kuwabara Tomoko
Taira Kazunari
Japan As Represented By Secretary Of Agency Of Industrial Scienc
Mccarthy Tetrault Llp
Taisho Pharmaceutical Co. Ltd.
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