Nucleic acid expressed in the hypothalamus or muscle tissue...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2437423

An isolated nucleic acid molecule comprising a sequence of nucleotides encoding or complimentary to a sequence encoding a molecule or derivative or homologue thereof wherein said nucleic acid molecule is expressed in a larger amount in one or both hypothalamus tissue or muscle tissue of obese animals compared to lean animals or in fed animals compared to fasted animals. Nucleic acid sequences are disclosed. It is proposed to use the expression products of such nucleic acids as modulators and/or monitors of physiological processes associated with obesity, anorexia, weight maintenance, impaired muscle development, diabetes and/or metabolic energy levels.

L'invention porte sur une molécule d'acide nucléique isolée comprenant une séquence de nucléotides codant ou complémentaire d'une séquence codant une molécule ou son dérivé ou son homologue. La molécule d'acide nucléique étant exprimée de manière plus importante dans un tissu d'hypothalamus et/ou un tissu musculaire chez les animaux obèses par rapport aux animaux minces ou chez les animaux affouragés par rapport aux animaux suivant un régime. L'invention porte également sur des séquences d'acide nucléique et vise à utiliser les produits d'expression desdits acides nucléiques comme modulateurs et/ou comme régulateurs des processus physiologiques associés à l'obésité, à l'anorexie, au maintien du poids, au développement musculaire déséquilibré, au diabète et/ou aux niveaux d'énergie métabolique.

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