A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/21 (2006.01) A61K 38/48 (2006.01) A61K 39/00 (2006.01) A61K 47/34 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2401327
A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes anionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly- acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.
L'invention concerne une formulation d'acide nucléique convenant pour le transfert de gènes, comprenant un acide nucléique et un polymère anionique. Le polymère anionique peut être par exemple un polymère d'acides aminés anionique ou un acide polyaminé (tel que l'acide poly-L-glutamique, l'acide poly-D-glutamique, l'acide poly-L-aspartique, l'acide poly-D-aspartique), un acide polyacrylique, des polynucléotides, un acide polygalacturonique, et un sulfate polyvinylique.
Fewell Jason G.
Maclaughlin Fiona
Nicol Francois
Rolland Alain
Smith Louis C.
Genetronics Inc.
Smart & Biggar
Valentis Inc.
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