C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 39/04 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2285625
The present invention is based on the identification and characterization of a number of M. tuberculosis derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86, 88, 90, 92, 94, 141, 143, 145, 147, 149, 151, 153, and 168-171). The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides. Another part of the invention is based on the surprising discovery that fusions between ESAT-6 and MPT59 are superior immunogens compared to each of the unfused proteins, respectively.
La présente invention concerne l'identification et la caractérisation d'un certain nombre de nouvelles protéines et de nouveaux fragments protéiques dérivés de M. Tuberculosis (SEC ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86, 88, 90, 92, 94, 141, 143, 145, 147, 149, 151, 153 et 168-171). l'invention concerne notamment des polypeptides et des fragments de ceux-ci, actifs sur le plan immunologique, les gènes codant ces polypeptides et fragments, ainsi que des compositions immunologiques telles que des vaccins et des réactifs d'essai cutanés contenant ces polypeptides. Une autre partie de l'invention concerne la découverte étonnante que des fusions entre ESAT-6 et MPT59 constituent des immunogènes supérieurs par rapport à chacune des protéines correspondantes non fusionnées.
Andersen Peter
Florio Walter
Oettinger Thomas
Rasmussen Peter Birk
Rosenkrands Ida
Sim & Mcburney
Statens Serum Institut
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