C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 35/74 (2006.01) C07K 14/01 (2006.01) C12N 1/06 (2006.01) C12N 1/08 (2006.01)
Patent
CA 2453518
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations. The invention also relates to a method comprising the steps of (a) providing bacterial cells comprising (i) a gene encoding a lytic protein capable of forming a tunnel structure in the bacterial membrane and (ii) a gene encoding an enzyme capable of hydrolyzing cytoplasmic components in the bacterial cells, (b) optionally cultivating the bacterial cells under conditions, wherein the lytic gene and the enzyme gene are not expressed, (c) subjecting the bacterial cells to conditions, wherein the lytic gene and the enzyme gene are expressed and the cytoplasmic components of the bacterial cells are degraded and liberated and (d) obtaining the resulting bacterial ghosts.
La présente invention concerne des préparations de fantômes bactériens sensiblement exempts de cellules bactériennes vivantes et/ou d'acides nucléiques, et leur utilisation dans des préparations pharmaceutiques.
Haidinger Wolfgang
Lubitz Werner
Lubitz Werner
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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