Nucleic acid immunization using a virus-based...

Details Nucleic acid immunization using a virus-based... Nucleic acid immunization using a virus-based...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C12N 15/85 (2006.01) C12N 15/863 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2191362

A method for nucleic acid immunization which results in a cell-mediated immunological response to a selected antigen is disclosed. The method utilizes the T7 RNA infection/transfection system which provides for the controlled, transient cytoplasmic expression of a given antigen and which elicits the production of class I MHC restricted CTLs.

L'invention concerne un procédé d'immunisation à l'acide nucléique permettant d'obtenir une réaction immunologique à médiation cellulaire par rapport à un antigène sélectionné. Ce procédé utilise le système d'infection/transfection d'ARN de T7, qui assure l'expression cytoplasmique transitoire et contrôlée d'un antigène donné et qui provoque la production de lymphocytes T cytotoxiques (CTL) limités par CMH de classe I.

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