Nucleic acid ligand inhibitors to dna polymerases

Details Nucleic acid ligand inhibitors to dna polymerases Nucleic acid ligand inhibitors to dna polymerases

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2362526

This invention discloses high-affinity oligonucleotide ligands to the thermostable Taq polymerase, Tth polymerase and TZ05 polymerase. Specifically, this invention discloses DNA ligands having the ability to bind to the Taq, Tth and TZ05 polymerases and the methods for obtaining such ligands. The ligands are capable of inhibiting polymerases at any predetermined temperature.

L'invention porte sur des ligands d'oligonucléotides présentant une forte affinité pour la polymérase Taq, la polymérase Tth, et la polymérase TZ05 et plus spécifiquement sur des ligands d'ADN pouvant se fixer aux polymérases Taq, Tth, et TZ05, et sur les méthodes d'obtention desdits ligands qui sont capables d'inhiber les polymérases à toute température prédéterminée.

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