Nucleic acid ligands

Details Nucleic acid ligands Nucleic acid ligands

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C12N 9/12 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) C12Q 1/37 (2006.01) C12Q 1/70 (2006.01) G01N 33/531 (2006.01) G01N 33/532 (2006.01) G01N 33/535 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) G01N 33/76 (2006.01) C07B 61/00 (2006.01) F02B 75/02 (2006.01)

Patent

CA 2084987

A new class of nucleic acid compounds, referred to as nucleic acid antibodies, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligand components of the nucleic acid antibodies are identified by the method of the invention referred to as the Systematic Evolution of Ligands by Exponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.

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