Nucleic acid ligands of tissue target

Details Nucleic acid ligands of tissue target Nucleic acid ligands of tissue target

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2219106

This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to peripheral blood mononuclear cells (PBMC), fibrin clots, and carotid arteries are described.

L'invention concerne des ligands oligonucléotidiques à forte affinité à des cibles tissulaires complexes, en particulier les ligands à acide nucléique ayant une capacité de liaison à des cibles tissulaires complexes. L'invention se rapporte aussi aux procédés qui permettent d'obtenir de tels ligands. Parmi les cibles tissulaires figurent les cellules, les constituants infracellulaires, les ensembles de cellules, les collections de cellules et différentes structures d'ordre plus élevé. On décrit spécifiquement des ligants à acide nucléique ayant une affinité avec les cellules mononucléaires du sang périphérique ainsi qu'avec les caillots fibrineux et les artères carotides.

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