Nucleic acid ligands of tissue target

Details Nucleic acid ligands of tissue target Nucleic acid ligands of tissue target

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01)

Patent

CA 2641149

This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to peripheral blood mononuclear cells (PBMC), fibrin clots, and carotid arteries are described.

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