Nucleic acid ligands of tissue target

Details Nucleic acid ligands of tissue target Nucleic acid ligands of tissue target

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2311164

This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to blood vessels are described.

Cette invention porte sur des ligands oligonucléotidiques de haute affinité se liant à des cibles tissulaires complexes, notamment des ligands d'acide nucléique ayant la capacité de se lier à des cibles tissulaires complexes, et sur des procédés permettant d'obtenir ces ligands. Les cibles tissulaires comprennent des cellules, des composants sous-cellulaires, des agrégats de cellules, des rassemblements de cellules et des structures extrêmement ordonnées. L'invention porte notamment sur des ligands d'acide nucléique se fixant aux vaisseaux sanguins.

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