Nucleic acid ligands to the prostate specific membrane antigen

Details Nucleic acid ligands to the prostate specific membrane antigen Nucleic acid ligands to the prostate specific membrane antigen

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2425605

Methods are provided for generating nucleic acid ligands of Prostate Specific Membrane Antigen (PSMA). The methods of the invention use the SELEX method for the isolation of nucleic acid ligands. The invention also includes nucleic acid ligands to PSMA, and methods and compositions for the treatment and diagnosis of disease using the nucleic acid ligands.

La présente invention concerne des procédés de génération de ligands d'acides nucléiques de l'antigène membranaire prostatique spécifique. Les procédés de l'invention utilisent la méthode de l'évolution systématique de ligands par enrichissement exponentiel (SELEX) pour isoler des ligands d'acides nucléiques. L'invention concerne également des ligands d'acides nucléiques de l'antigène membranaire prostatique spécifique et des procédés et des compositions pour le traitement et le diagnostic des maladies mettant en oeuvre les ligands d'acides nucléiques.

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