Nucleic acid-lipophilic conjugates

Details Nucleic acid-lipophilic conjugates Nucleic acid-lipophilic conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 37/02 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2536139

The present invention relates in part to immunostimulatory nucleic acids linked to a lipophilic group. It has been deiscovered that specific immunostimulatory nucleic acids linked to lipophilic groups have enhanced activity, whereas the linkage of lipophilic groups to other immunostimulatory nucleic acids has minimal effect on the immunostimulatory capability of the molecule.

L'invention concerne des conjugués lipophiles d'acides nucléiques, ainsi que des méthodes de modulation de réponse immunitaire mettant en oeuvre lesdits conjugués. L'invention concerne également le groupe fonctionnel lipophile associé à un acide nucléique immunostimulateur.

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