A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/19 (2006.01) A61K 9/00 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2695901
Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
L'invention concerne des compositions, des méthodes et des applications qui augmentent l'efficacité de transfection d'acides nucléiques. Selon un aspect, une composition pharmaceutique peut comprendre une concentration d'au moins environ 0,5 mg/ml d'un acide nucléique condensé avec un lipopolymère cationique en suspension dans une solution isotonique, le lipopolymère cationique comprenant un squelette polymère cationique présentant du cholestérol et du polyéthylène glycol liés de manière covalente audit squelette, le rapport molaire du cholestérol sur le squelette polymère cationique étant compris dans une plage d'environ 0,1 à environ 10, et le rapport molaire de polyéthylène glycol sur le squelette polymère cationique étant compris dans une plage d'environ 0,1 à environ 10. La composition peut également comprendre un excipient de charge.
Anwer Khursheed
Fewell Jason
Lewis Danny H.
Matar Majed
Egen Inc.
Osler Hoskin & Harcourt Llp
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