Nucleic acid mediated electron transfer

Details Nucleic acid mediated electron transfer Nucleic acid mediated electron transfer

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2257534

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

L'invention concerne la modification covalente sélective d'acides nucléiques par des fractions actives redox comme les complexes de métaux de transition. Les fractions donneurs d'électrons et accepteurs d'électrons sont mises en liaison covalente avec l'ossature ribose/phosphate d'un acide nucléique en des emplacements préétablis. Les complexes résultants constituent une série de nouveaux dérivés qui représentent des matrices bimoléculaires capables d'assurer le transfert d'électrons sur de très grandes distances à des vitesses extrêmement rapides. Ce type de complexe présente des caractéristiques structurales uniques qui permettent d'utiliser une catégorie inédite de bioconducteurs et de sondes photosensibles.

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