C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2178618
The present invention provider for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. There complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
L'invention concerne la modification covalente sélective d'acides nucléiques au moyen de fractions redox actives. Les fractions donneuses d'électrons et réceptrices d'électrons sont liées de manière covalente au squelette ribose-phosphate d'un acide nucléique au niveau de positions prédéterminées. Les complexes résultants représentent une série de nouveaux dérivés constituant des matrices bimoléculaires capables de transférer des électrons sur de très longues distances et à des vitesses extrêmement élevées. Ces complexes présentent des caractéristiques structurales uniques permettant l'utilisation d'une classe entièrement nouvelle de bioconducteurs et de sondes photoactives.
Fraser Scott E.
Kayyem Jon Faiz
Meade Thomas J.
California Institute Of Technology
Smart & Biggar
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