Nucleic acid microparticles for pulmonary delivery

Details Nucleic acid microparticles for pulmonary delivery Nucleic acid microparticles for pulmonary delivery

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2682135

The present disclosure is related to microparticle compositions, in which the microparticles are made of nucleic acids and non-polymeric cations, which are suitable for administration to moist or aqueous target locations (e.g., the lung tissue), where the substantially spherical nucleic acid microparticles release the nucleic acids through dissolution, allowing the released nucleic acids to freely interact with the target cells.

La présente invention concerne des compositions de microparticules, les microparticules étant constituées d'acides nucléiques et de cations non polymères et les combinaisons pouvant être administrées dans des emplacements cibles humides ou aqueux (par exemple le tissu pulmonaire). Les microparticules d'acides nucléiques pratiquement sphériques libèrent les acides nucléiques par dissolution, ce qui permet aux acides nucléiques libérés d'interagir librement avec les cellules cibles.

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