Nucleic acid mismatch detection

Details Nucleic acid mismatch detection Nucleic acid mismatch detection

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 27/02 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2516647

In one aspect, the invention provides methods and apparatus for detecting a mismatch in a nucleic acid duplex by measuring the impedence of a nucleic acid layer on an electrode, for example by AC impedance spectroscopy.

Dans un mode de réalisation, l'invention concerne des procédés et des appareils permettant de détecter un mésappariement dans un duplexe d'acides nucléiques et consistant à mesurer l'impédance d'une couche d'acide nucléique sur une électrode, par exemple, au moyen de la spectrométrie d'impédance CA.

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