Nucleic acid molecules encoding a transmembrane serine...

Details Nucleic acid molecules encoding a transmembrane serine... Nucleic acid molecules encoding a transmembrane serine...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12N 11/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/79 (2006.01) C12P 21/00 (2006.01) G01N 33/543 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2447050

Provided herein are type II transmembrane serine protease 10 (MTSP10) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the activity of an MTSP10 are provided.

L'invention concerne des polypeptides de sérine protéase transmembranaire 10 (MTSP10) de type II, un zymogène et des formes activées de ces polypeptides, ainsi que des formes monocaténaires et bicaténaires du domaine protéasique. L'invention concerne en outre des méthodes d'utilisation de ces polypeptides en vue d'identifier des composés modulant l'activité d'une sérine protéase MTSP10.

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