Nucleic acid molecules encoding transmembrane serine...

Details Nucleic acid molecules encoding transmembrane serine... Nucleic acid molecules encoding transmembrane serine...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 15/57 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2396774

Provided herein are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided are MTSPs designated MTSP3 and MTSP4 and a form of an MTSP designated MTSP6.

L'invention concerne des polypeptides comportant un domaine de protéase du type de protéase à sérine transmembranaire de type II (MTSP) sous forme d'une chaîne unique. Elle concerne aussi des procédés utilisant ces polypeptides afin d'identifier des composés qui modulent l'activité protéase d'une MTSP. Elle concerne encore des MTSP de désignation MTSP3 et MTSP4 ainsi qu'une forme de MTSP de désignation MTSP6.

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