C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2339131
The invention relates to a method for isolating nucleic acid molecules which are capable of specific interaction with native PrPSc and can differentiate between native PrPc and native PrPSc. The inventive method comprises the following steps: incubating a pool of nucleic acids with purified PrPSc preparations (PPPs); selecting and isolating the resulting protein/nucleic acid complexes and optionally amplifying the specific nucleic acids, in addition to optionally repeating the incubation and isolation stage. The invention also relates to the nucleic acid molecule produced by this method and the use thereof for diagnosing and treating transmissible spongiform encephalopathies.
L'invention concerne un procédé pour l'isolation de molécules d'acides nucléiques aptes à l'interaction spécifique avec la PrP?Sc¿ native et à la distinction de la PrP?c¿ native et de la PrP?Sc¿ native. Le procédé selon l'invention comporte les étapes suivantes : incubation d'un ensemble d'acides nucléiques avec des préparations PrP?Sc¿ purifiées (PPP), sélection et isolation des complexes protéines/acides nucléiques obtenus et, éventuellement, amplification des acides nucléiques spécifiques ainsi que répétition éventuelle de l'étape d'incubation et d'isolation. L'invention concerne également la molécule d'acide nucléique ainsi obtenue et son utilisation pour le diagnostic et le traitement d'encéphalopathies spongiformes transmissibles.
Ridout & Maybee Llp
Weiss Stefan
LandOfFree
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